Brain and Blood Biomarkers of Major Depressive Disorder
This systematic review evaluates brain and blood biomarkers associated with major depressive disorder.
Development of Major Depressive Disorder—Does Insulin Resistance Play a Role?
To the Editor We read with great interest the study by Edwin Thanarajah et al published in JAMA Psychiatry. The authors present important findings on the association between soft drink consumption and the presence of depressive symptoms in patients with major depressive disorder (MDD). Their analyses further suggest that this association is mediated by increased […]
Development of Major Depressive Disorder—Does Insulin Resistance Play a Role?—Reply
In Reply We thank van Bruggen and McIntyre for their thoughtful and constructive comment on our article in JAMA Psychiatry. The proposed link between insulin resistance and the soft drink-microbiome-depression pathway is compelling and well supported by accumulating evidence on metabolic contributions to major depressive disorder (MDD).
Predicting Adolescent Response to School-Based Mindfulness
This secondary analysis of a cluster trial uses school-level nested cross-validation to train and evaluate machine learning models for predicting individualized benefit from school-based mindfulness training.
JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians and researchers in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform its readers, to stimulate discussion into the nature, causes, treatment, and public health importance of mental illness, and to promote equity and […]
Covariation of symptomatic and mechanistic change during dialectical behavior therapy for suicidal self-harming youth.
Journal of Consulting and Clinical Psychology, Vol 94(2), Feb 2026, 63-73; doi:10.1037/ccp0000986 Objective: The effectiveness of psychotherapy for suicidal youth remains a public health priority. Dialectical behavior therapy (DBT; Linehan, 1993) has been recognized as a well-established treatment for suicidal youth (Witt et al., 2021). Although promising, little work has explored mechanisms of change in […]
A randomized controlled trial of injunctive norms feedback with and without motivational interviewing to reduce alcohol use and negative consequences among college students.
Journal of Consulting and Clinical Psychology, Vol 94(2), Feb 2026, 74-87; doi:10.1037/ccp0000989 Objective: Personalized normative feedback interventions targeting perceived descriptive norms (perceptions of how much or how often other people drink) have repeatedly been shown to reduce problem drinking among young adults. Less work has targeted perceived injunctive norms (perceptions of others’ approval of drinking), […]
Therapist effects in internet-delivered cognitive behavior therapy for anxiety and depression.
Journal of Consulting and Clinical Psychology, Vol 94(2), Feb 2026, 88-100; doi:10.1037/ccp0000994 Objective: Several clinical studies have found that therapists differ in their client outcomes, supporting the notion of “therapist effects” in psychotherapy. However, only a handful of studies have investigated therapist effects in internet-delivered cognitive behavior therapy. This study aimed to examine therapist effects […]
Cost-effectiveness of transdiagnostic group cognitive behavioral therapy for emotional disorders in primary care: An analysis of the PsicAP clinical trial.
Journal of Consulting and Clinical Psychology, Vol 94(2), Feb 2026, 101-113; doi:10.1037/ccp0000990 Objective/s: Transdiagnostic cognitive behavioral therapy has proven to be an effective treatment for emotional disorders. However, the cost-effectiveness of group Transdiagnostic cognitive behavioral therapy remains unknown. Given the growing demand for psychological care in primary care in the context of limited resources, an […]
Examining theoretical mediators in a culturally adapted, community health worker-led intervention for depression and anxiety.
Journal of Consulting and Clinical Psychology, Vol 94(2), Feb 2026, 114-123; doi:10.1037/ccp0000995 Objective: Emerging research suggests that mental health interventions led by community health workers (CHW) are effective and increase access to services for minoritized groups. However, the question of how these interventions work has rarely been tested. In this secondary analysis of data from […]