JAMA Psychiatry

Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians and researchers in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform its readers, to stimulate discussion into the nature, causes, treatment, and public health importance of mental illness, and to promote equity and […]

Neuroplastogen Treatment for Posttraumatic Stress Disorder

To the Editor In JAMA Psychiatry, Jones and colleagues report compelling phase 2 data on TSND-201, suggesting rapid and durable reductions in posttraumatic stress disorder (PTSD) symptoms after a brief, intermittent dosing regimen. Several aspects of the trial design raise questions that may help readers more fully contextualize the observed effects.

Ambient AI and Measurement Bias in Psychiatric Notes

To the Editor In JAMA Psychiatry, Castro and colleagues reported that ambient artificial intelligence (AI) scribe use during primary care visits was associated with higher large language model (LLM)–estimated Research Domain Criteria (RDoC) symptom documentation across all 6 domains yet lower odds of a documented psychiatric intervention (depression-related International Statistical Classification of Diseases and Related […]

Ambient AI and Measurement Bias in Psychiatric Notes—Reply

In Reply We thank Bair for his thoughtful suggestions for future work, extending our prior investigations of dimensional characterization of narrative notes. Real-world evidence, ideally from randomized clinical trials, will be crucial to examine the impact of widespread adoption of language models in clinical settings.

Mental health benchmarks in the United States: An unheeded call to action.

Journal of Consulting and Clinical Psychology, Vol 94(5), May 2026, 253-255; doi:10.1037/ccp0001012 Despite longstanding calls for standardized benchmarks in U.S. outpatient mental health care, none are widely adopted, limiting the ability to evaluate outcomes, compare providers, and advance measurement-based care (MBC). Benchmarks—defined as expected outcome distributions adjusted for diagnosis, severity, and treatment dose—would make care […]

Complete delivery matters: Multilevel complier average causal effect analysis of universal mental health curricula in two randomized controlled trials in U.K. schools.

Journal of Consulting and Clinical Psychology, Vol 94(5), May 2026, 267-280; doi:10.1037/ccp0000997 Objective: Complete implementation is assumed in intention-to-treat analyses of universal, school-based mental health literacy curricula, but implementation data routinely reveal program delivery is often incomplete (or in extreme cases, no implementation occurs). Complier average causal effect estimation can rigorously determine whether this makes […]

Dysfunctional attitudes in cognitive–behavioral therapy and antidepressant pharmacotherapy for adult depression: A systematic review and meta-analysis of individual participant data.

Journal of Consulting and Clinical Psychology, Vol 94(5), May 2026, 281-292; doi:10.1037/ccp0001001 Objectives: Dysfunctional attitudes (DA) constitute a vulnerability factor for depression that might be most effectively targeted with cognitive–behavioral therapy (CBT), but evidence is inconclusive. This individual participant data meta-analysis examined DA change during CBT and antidepressant medication, potential pathways of change by exploring […]

Effectiveness of stepped counseling on depression in distressed family caregivers of older adults: A randomized pragmatic trial (ReDiCare).

Journal of Consulting and Clinical Psychology, Vol 94(5), May 2026, 293-304; doi:10.1037/ccp0001004 Objective: The high prevalence of depressive symptoms among family caregivers of older adults dependent on care highlights the need for interventions for reducing depression. Stepped-care approaches of evidence-based interventions have not yet been evaluated in routine settings despite their potential to tailor interventions […]