JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians and researchers in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform its readers, to stimulate discussion into the nature, causes, treatment, and public health importance of mental illness, and to promote equity and […]
Patients Use AI—Clinicians Should Ask How
This article discusses the increasing prevalence of individuals seeking mental health help from artificial intelligence (AI) and recommends strategies to help patients navigate AI use.
Interventions for Bereavement
This Viewpoint explores the effectiveness of various interventions for individuals experiencing grief disorders, particularly prolonged grief disorder, following the death of a loved one.
Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia
This genetic association study tests whether genetically driven variability in excitatory neurons’ transcriptome and synapse density in patient-derived neurons in vitro explain individual changes in cortical morphology, electrophysiology, and cognitive impairments in vivo.
Enlightenment in a Pill—Testing the Efficacy of Psilocybin
Can a guided psychedelic experience with psilocybin successfully treat refractory depression? In other words, setting aside any simple direct biological drug effect, can psychedelic-assisted psychotherapy alleviate suffering via what William James would call a mystical experience?
Predicting Adolescent Response to School-Based Mindfulness
This secondary analysis of a cluster trial uses school-level nested cross-validation to train and evaluate machine learning models for predicting individualized benefit from school-based mindfulness training.
JAMA Psychiatry
Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians and researchers in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform its readers, to stimulate discussion into the nature, causes, treatment, and public health importance of mental illness, and to promote equity and […]
Brain and Blood Biomarkers of Major Depressive Disorder
This systematic review evaluates brain and blood biomarkers associated with major depressive disorder.
Development of Major Depressive Disorder—Does Insulin Resistance Play a Role?
To the Editor We read with great interest the study by Edwin Thanarajah et al published in JAMA Psychiatry. The authors present important findings on the association between soft drink consumption and the presence of depressive symptoms in patients with major depressive disorder (MDD). Their analyses further suggest that this association is mediated by increased […]
Development of Major Depressive Disorder—Does Insulin Resistance Play a Role?—Reply
In Reply We thank van Bruggen and McIntyre for their thoughtful and constructive comment on our article in JAMA Psychiatry. The proposed link between insulin resistance and the soft drink-microbiome-depression pathway is compelling and well supported by accumulating evidence on metabolic contributions to major depressive disorder (MDD).